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people with long-term illness such as cancer are frequently treated with glucocorticoids, making cachexia more likely in these individuals.

Some tumors produce a molecule called parathyroid-related peptide (PTHrP). It increases metabolism by stimulating energy production in the mitochondria of fat cells.

Leptin is a hormone known to decrease appetite. People with cachexia often have high leptin levels, making them feel less hungry.

The hypothalamus,

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