instance with alkyl halides in a key step in industrial Naproxen production:

Reactions as a base

Grignard reagents are basic and react with alcohols, phenols, etc. to give alkoxides (ROMgBr). 1,3-Diketones and related substrates are also acidic enough that the Grignard reagent RMgX functions merely as a base, liberating the alkane RH to give a magnesium enolate.

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