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are never complete, given the limitations of experimental methods. For instance, it has been estimated that typical Y2H screens detect only 25% or so of all interactions in an interactome. The coverage of an interactome can be assessed by comparing it to benchmarks of well-known interactions that have been found and validated by independent assays. Other methods filter out false positives calculating the similarity of known annotations of the proteins involved or define a likelihood of interaction using

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