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morphology, holding the two heavy chains together (imagine two snakes wrapped around each other, as in a caduceus). Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. In smooth muscle, a single gene (MYH11)) codes for the heavy chains myosin II, but splice variants of this gene result in four distinct isoforms.
* It also contains 4 myosin light chains

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