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folds could be more sensitive to genetic and environmental factors. The first gene reported to influence gyrification was Trnp1. Local expression levels of Trnp1, can determine the future position of developing folds/gyri in human brains. Genes that influence cortical progenitor dynamics, neurogenesis and neuronal migration, as well as genes that influence the development of cortical circuits and axonal projections may all contribute to gyrification. Trnp1 is a DNA-binding factor that

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