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roles both in inter and intra nucleosomal interactions that ultimately influence gene access. Histones are positively charged molecules which allow a tighter bonding to the negatively charged DNA molecule. Reducing the positive charge of histone proteins reduces the strength of binding between the histone and DNA, making it more open to gene transcription (expression). Moreover, these flexible units direct DNA wrapping in a left-handed manner around the histone octamer during nucleosome formation. Once the DNA is bound the tails continue to interact

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