over a period of time, that results in the fatality of an individual animal. LC_Lo is typically for an acute (<24 hour) exposure. It is related to the LC_{50, the median lethal concentration. The LC_Lo is used for gases and aerosolized material.}

Limitations

As a measure of toxicity, lethal dose is somewhat unreliable and results may vary greatly between testing facilities due to factors such as the genetic characteristics of the sample population, animal species tested, environmental factors and

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