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cartilage and bone formation. The neural tube activates the protein WNT1 that expresses PAX 2 so the somite creates the myotome and dermatome. Finally, the neural tube also secretes neurotrophin 3, so that the somite creates the dermis. Boundaries for each somite are regulated by retinoic acid and a combination of FGF8 and WNT3a. So retinoic acid is an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation and controls bilateral symmetry in

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