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<p>of <a href="page.php?w=fixation_%28population_genetics%29">fixation</a>--when it either disappears from the population or replaces the ancestral allele entirely.</p>

<p><big> Mutation </big></p>
<p>Mutations are changes in the DNA sequence of a cell's genome and are the ultimate source of genetic variation in all organisms. When mutations occur, they may alter the <a href="page.php?w=gene_product">product of a gene</a>, or prevent the gene from functioning, or have no effect.</p>

<p>About half of the mutations in the coding regions of protein-coding</p><p>
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