In the presence of a certain gene variation (APOE-epsilon4 allele carriers), HSV-1 appears to be particularly damaging to the nervous system and increases one's risk of developing Alzheimer's disease. The virus interacts with the components and receptors of lipoproteins, which may lead to its development.

Pathophysiology

Herpes is contracted through direct contact with an active lesion or body fluid of an infected person. Herpes transmission occurs

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