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have been lost, increasing the occurrence of deletion mutations. Because the products supplied by these deleted genes are typically present in the host cells infected by Mycobacterium leprae, the impact that the mutations have on the microbe is minimal, allowing for survival within the host despite its reduced genome. Consequently, Mycobacterium leprae has undergone a dramatic reduction in genome size with the loss of many genes. Over half of the pathogen's genome is now made up by pseudogenes

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