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for in many neurons is quite negative, nearly equal to the resting potential. Opening channels tends to buffer the membrane potential, but this effect is countered when the membrane starts to depolarize, allowing more negatively charged ions to enter the cell. Consequently, it becomes more difficult to depolarize the membrane and excite the cell when channels are open. Similar effects result from the opening of channels. The significance of inhibitory neurotransmitters is evident from the effects

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