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4 (PDE4) inhibitors, such as Rolipram, cause emesis as one of their side effects. It has been found that these PDE4 isoforms are expressed in the CTZ and in the brainstem in general. The mRNA products from genes that code for these PDE4 isoforms are plentiful in the CTZ, and not only located in CTZ neurons, but also in glial cells and blood vessels associated with the CTZ neurons. PDE4 mRNAs are transcribed more

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