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of the pulp, leaving behind microtubules filled with cytoplasmic extensions and depositing intertubular dentin (ITD) in its place. ITD comprises the bulk of the dentin and, similarly to bone, is a matrix composite of tablet-shaped hydroxyapatite nanoparticles wrapped around collagen fibers. The mineralized collagen fibers are arranged in layers oriented perpendicular to the direction of the dentin microtubules

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