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<p>which interfere with the normal <a href="page.php?w=Arginine">L-arginine</a>-stimulated <a href="page.php?w=Nitric_oxide_synthase">nitric oxide synthesis</a> and so leads to hypertension. The most prevailing mechanism of endothelial dysfunction is an increase in <a href="page.php?w=reactive_oxygen_species">reactive oxygen species</a>, which can impair nitric oxide production and activity via several mechanisms. The signalling protein <a href="page.php?w=ERK5">ERK5</a> is essential for maintaining normal endothelial cell function. A further consequence</p><p>
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