and acenocoumarol) are used. These agents known as vitamin K antagonists (VKA), inhibit the vitamin K-dependent carboxylation of Factors II (prothrombin), VII, IX, X in the hepatocyte. This carboxylation after the translation is essential for the physiological activity.

Heparin (unfractionated heparin) and its derivatives low molecular weight heparin (LMWH) bind to a plasma