Principles

Antibody-mediated opsonisation (marking) of pathogens depends on high affinity paratope-epitope interactions. Immunoglobulins are highly effective opsonins, with the IgG subclasses IgG1 and IgG3 being recognised as the most efficacious opsonins in humans.

Antibodies structurally contain two important domains

# Fab domain - the region of the antibody which displays the paratope capable of binding to antigenic epitopes
# '''Fc''' fragment

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