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activity of the Lysyl-tRNA synthetase (LysRS). This function of LysRS is activated by the phosphorylation of LysRS on serine 207, its subsequent dissociation from the multi-synthetase complex (MSC). The molecule's role as a second messenger has recently been discovered in The LysRS-Ap4A-MITF signaling pathway. Ap4A binds to the MITF-HINT1 inhibitory complex, specifically to the molecule histidine triad nucleotide-binding protein 1(HINT1),

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