solely for use on Blue Origin's proprietary launch vehicle, the New Glenn, the engine was also selected in 2014 by United Launch Alliance (ULA) for its Vulcan Centaur rocket, which replaces the Atlas V and Delta IV. ULA finalized the BE-4 as its choice in September 2018.

The BE-4 made its first flight aboard the Vulcan Centaur rocket on January 8, 2024.