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<p>the town has been the most important trade and manufacturing centre of the area for centuries. After the fall of the <a href="page.php?w=Roman_Empire">Roman Empire</a>, Casale became a free municipality and, in the 15th and early 16th centuries, served as the capital of the <a href="page.php?w=House_of_Palaiologos">House of Palaiologos</a>. Then in 1536, the town passed to the <a href="page.php?w=House_of_Gonzaga">Gonzagas</a> who fortified it with a large citadel. In the 17th century, Casale was heavily involved in the <a href="page.php?w=War_of_the_Mantuan_Succession">War of the Mantuan Succession</a></p><p>
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