Natalis joined the Dominicans in 1276. In 1303, he entered the convent of St. Jacques at the University of Paris. On his arrival to St. Jacques, he signed a petition supporting Philip the Fair's attempt to convoke a council in his war with Pope Boniface VIII on grounds of papal jurisdiction.

He studied theology in Paris and became French provincial of the Dominicans in 1308. Later in 1318, he was appointed Master General of the Order.

A resolute early Thomist, nicknamed Doctor rarus, he was

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