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<p>bonded modifications include <a href="page.php?w=acetylation">acetylation</a> and <a href="page.php?w=methylation">methylation</a> of the N-terminal tails. These modifications may alter <a href="page.php?w=Gene_expression">expression of genes</a> located on DNA associated with its parent histone octamer. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.</p>

<p><big>Genetics</big></p>
<p>Histone</p><p>
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