in 1684. Ruins of the fortress that remain are called Recycle and are part of the old town wall. The center of the old part of Opuzen is a classic Roman Forum. In the Middle Ages, Opuzen was known as Posrednica. The Republic of Ragusa in the 14th century had major trading markets (mainly trading in salt) in Opuzen. The markets got burnt down in 1472. The first Community School was opened in 1798 and was the only school in the Neretva region until 1845.

In the town is located Opuzen's Parish