is a cell formation in a halo or spoke-and-wheel arrangement, surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core: the nuclei of the cells participatingin the rosette are peripherally positioned and form a ring or halo around the hub.

Pathogenesis

Rosettes may be considered primary or secondary manifestations of tumor architecture.

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