May 1288, receiving from the then Pope Nicholas IV the title of cardinal-deacon S. Eustachio. He signaled the papal bulls between 3 September 1288 and 21 June 1295. Colonna received a number of beneficiaries in the diocese of Rome, among others churches. He participated in the papal election of 1292-1294 and the conclave of 1294.

In 1297, a conflict broke out between Pope Boniface VIII