to enter the cell. This in turn depolarizes the cell and opens voltage-gated calcium channels, flooding the cell with positive calcium ions and leading to neurotransmitter release. ENaC can be blocked by the drug amiloride in many mammals, particularly rats. The sensitivity of the low-salt taste to amiloride in humans is much less pronounced, leading to speculation that there may be additional low-salt receptors besides ENaC to be discovered.

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