Manuel Rodriguez was born March 2, 1940, in Buffalo, New York. He picked up the nickname Spain as a child, when he heard some kids in the neighborhood bragging about their Irish ancestry, and he defiantly claimed Spain was just as good as Ireland. Rodriguez studied at the Silvermine Guild Art School in New Canaan, Connecticut alongside cartoonist M.K. Brown.

"When Manuel Spain Rodriguez ditched art school in 1959, the decision came easily. The Silvermine Guild School of Art professors didn't appreciate his representational drawings, an alcoholic landlord threatened his life, and he'd witnessed a good friend commit suicide. So he returned to his hometown of Buffalo, New York, where he painted, took a janitor job (at the Western Electric plant for five years), became invested in left wing politics, and joined an outlaw motorcycle gang. Rodriguez's experiences as a member of the Road Vultures Motorcycle Club later manifested in black-and-white illustrations when he moved to Manhattan."