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1941 for the diagnosis of cervical lesions, numerous cytological observations were made over a short period of time. In 1951, the Canadian gynaecologist/cytologist James Ernest Ayre described and illustrated halo cells while working in Miami. He described these squamous cells of the uterine cervix to be having a perinuclear clearing, mono or bi-nucleate with poor keratinizing features and hyperchromatic atypical nuclei. He also proposed that these vacuolated cells were pre-cancerous and being always found

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