Whereas "normal" (''cis''-)splicing processes a single molecule, trans-splicing generates a single RNA transcript from multiple separate pre-mRNAs. This phenomenon can be exploited for molecular therapy to address mutated gene products. Genic trans-splicing allows variability in RNA diversity and increases proteome complexity.

Oncogenesis

While some fusion transcripts occur via trans-splicing in normal human cells, trans-splicing can also be

1.Previous
3.Next