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Those that are larger than 2mm have a higher chance of developing into oro-antral fistula (OAF). The passage is only defined as an OAF if it is persistent and lined by epithelium. Epithelialisation happens when an OAC persist for at least 2-3 days and oral epithelial cells proliferate to line the defect. Large defects (more than 2mm) should be surgically closed as soon as possible to avoid accumulation of food and saliva which could contaminate the maxillary sinus,

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