varying depending on the individual's CYP2C9 genetic profile.

Caution must be exercised with concomitant use of 2C9 inhibitors, such as fluconazole, which can greatly elevate celecoxib serum levels. If used concomitantly with lithium, celecoxib increases lithium plasma levels. If used concomitantly with warfarin, celecoxib may result in an increased risk of bleeding complications. The risk of bleeding and gastric ulcers also increases further when selective serotonin reuptake inhibitors