total Vimentin, phosphorylated Vimentin (S39) and Par6 in metastatic melanoma cells. These results suggested that PKC-? is involved in signaling pathways which upregulate EMT in melanoma thereby directly stimulates metastasis.

Recently, a series of high-profile experiments suggests that the co-option of intercellular cross-talk mediated by exosome vesicles is a critical factor involved in all steps of the invasion-metastasis cascade.

Routes

Metastasis occurs by the following four routes:

Transcoelomic

The

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