binds with its receptors (GPVI receptor and integrin ?2?1) on the platelet. GPVI is associated with the Fc receptor gamma chain and leads via the activation of a tyrosine kinase cascade finally to the activation of PLC-gamma2 (PLCG2) and more calcium release.

Tissue factor also binds to factor VII in the blood, which initiates the extrinsic coagulation cascade to increase