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factors induce myotome cells to produce MyoD protein--thereby causing them to develop as muscle cells. A transcription factor (TCF4) of connective tissue fibroblasts is involved in the regulation of myogenesis. Specifically, it regulates the type of muscle fiber developed and its maturations. Low levels of TCF4 promote both slow and fast myogenesis, overall promoting the maturation of muscle fiber type. Thereby this shows the close relationship of muscle with connective tissue

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