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<p>Windup is associated with <a href="page.php?w=chronic_pain">chronic pain</a> and central sensitization. This minimum frequency was determined experimentally by comparing healthy patient <a href="page.php?w=functional_magnetic_resonance_imaging">fMRI's</a> when subjected to varying frequencies of heat pulses. The fMRI maps show common areas activated by the TSSP responses which include contralateral thalamus (THAL), S1, bilateral S2, anterior and posterior insula (INS), mid-anterior <a href="page.php?w=cingulate_cortex">cingulate cortex</a> (ACC),</p><p>
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