differentiation in myogenesis. In mice lacking this gene, severe muscle hypoplasia affected most of the body muscles, specifically hypaxial muscles.

In myoblasts, PtdIns5P, produced by the lipid phosphatase MTM1, is rapidly metabolized by PI5P 4-kinase ? into PI(4,5)P2, which accumulates at the plasma membrane. This accumulation facilitates the formation of podosome-like protrusions, where the fusogen Myomaker is localized, playing a crucial role in the spatiotemporal regulation of myoblast fusion.

Protein synthesis and actin heterogeneity

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