caused by the firing of the inhibitory neuron causes the toxin to be pulled into the neuron inside vesicles.

Membrane translocation

The toxin then needs a way to exit the vesicle and enter the neuron cytosol to act on its target. The low pH of the vesicle lumen causes a conformational change in the toxin, shifting it from a water-soluble form to a hydrophobic form. With the hydrophobic patches exposed, the toxin can slide into the vesicle membrane. The toxin forms an ion channel

1.Previous
3.Next