widening the nuclear pore and allowing the entry of mitotic regulators.

Preservation of integrity

In fungi undergoing closed mitosis, where the nucleus remains intact, changes in the permeability barrier of the nuclear envelope are attributed to alterations within the NPC. These changes facilitate the entry of mitotic regulators into the nucleus. Studies in Aspergillys nidulans suggest that the NPC composition appears to be effected by the mitotic kinase NIMA. NIMA

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