OBE.Professor Bryan Williams OBE became the charity's first Chief Scientific and Medical Officer (CSMO) in December 2023, after Professor Sir Nilesh Samani stood down as Medical Director after more than 7 years in the role.

The BHF's Board of Trustees is made up of up to 14 Trustees, and is a mix of medically-qualified and lay members:
* Mark Ashton-Rigby
* David Boynton
* Dr Sarah Clarke
* Roisin Donnelly
* Professor Sadaf Farooqi