DNA fragmentation and chromatin condensation during apoptosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene; however, the biological validity of some variants has not been determined.

thumbDespite this gene being present in every cell, the protein it encodes is only expressed in various tissues and cell types, including the pancreas, heart, colon, leukocytes, prostate, ovary, placenta, kidney, spleen and thymus.