Comayagua is known today as "La Antañona" by Hondurans. They call it that because in addition to being one of the oldest cities in Honduras, it still maintains a large part of its buildings with architectural value from the colonial era. Its historic center "is the most restored and preserved nationwide."

The Spaniards named the place "Valladolid" or "País de las Higueras" , but the city formally kept the original, indigenous name of the place. Some