on the lagging strand. The Pol ? complex (pol ?-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Once primase has created the RNA primer, Pol ? starts replication elongating the primer with ~20 nucleotides.

Structure

DNA polymerase alpha, like DNA primase, contains iron-sulfur clusters, that are critical in electron transport

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