Arta and Rio. The road was removed from the old network, when the northern end of E19 was rerouted from Ioannina to Igoumenitsa, replacing the short-lived E106.

The Ioannina-Kakavia national road became part of the E-road network again, with the introduction of the original E851 on 15 March 1983. On 12 September 1986, the original E851 became the E853, and the E851 number was reused for the E-road from Petrovac