The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol.

HMGB1 has been shown to play an important role in helping the RAG endonuclease form a paired complex during V(D)J recombination.

Role in inflammation

HMGB1 is secreted by immune cells (e.g. macrophages,

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