and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.

Function

IL-8, also known as monocyte-derived neutrophil chemotactic factor (MDNCF), has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes,

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