May 12, 2010, Entertainment Weekly reported that Lie to Me received a 13-episode third season pick-up. The third season of Lie to Me was originally set to premiere on November 10, 2010. On September 28, 2010, the date was moved up to October 4, 2010, because of the cancellation of Lone Star. On May 11, 2011, Fox canceled Lie to Me after three seasons.

The show is inspired by the work of Paul Ekman, a specialist