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<p>or problematic, one of the biggest potential issues being the <a href="page.php?w=Telomere">end replication problem</a>. This is a phenomenon which occurs due to the directionality of DNA replication enzymes, resulting in the gradual loss of genetic material at the ends of linear chromosomes after each subsequent cycle of cell and DNA replication. In order to mitigate the negative effects of this gradual loss of genetic material, eukaryotes have evolved repetitive, <a href="page.php?w=Non-coding_DNA">non-coding</a> terminal DNA sequences known</p><p>
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