via Whipps Cross and Woodford replacing route 9.

On 28 October 1909, route 22 was changed again to work between Tulse Hill and Leyton via Effra Road, Brixton Road, Kennington Park Road, Elephant & Castle and Whipps Cross. On 3 January 1910, it was cut back again to work Clapton (Lea Bridge station) to Tulse Hill.