mechanical activation of the channel causes depolarisation of the Merkel cell and consequent release of serotonin into a synapse with the associated nerve ending, to also depolarise the later. The nerve ending, meanwhile, expresses an unknown mechanosensitive channel.

Location

Merkel nerve endings have a widely distributed in glabrous and hairy skin, in hair follicles, and in oral and anal mucosa.

Meckel nerve

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