George Davenport in 1833. Muscatine was incorporated as Bloomington in 1839; the name was changed to reduce mail delivery confusion, as there were several Bloomingtons in the Midwest. Before that, Muscatine had also been known as "Newburg" and "Casey's Landing".

The origin of the name Muscatine is debated. It may have been derived from the Mascouten Native American tribe. The Mascoutin lived along the Mississippi in the 1700s. In 1819 Muscatine Island was known